If you are born tone deaf and someone sings out of tune, do you feel discomfort? You certainly do. Your brain senses discomforting sound whether your conscious self can sense it or not. You will probably leave the room first if you are a music professional.
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Drawing one's nail over a blackboard will stir up many people. However, others are not disturbed at all. Individuals do differ, but everyone has this "warning" system built in. Though the list of things that have this effect are not the same for all.
It seems odd for someone to suggest that it is a medical condition. When disturbed most suffer in silence. The really sensitive do make a "song and dance" about it. Misophonia is when a person is so disturbed that the "fight or flight" reaction is triggered.
Scientists claim that MRI scans of frontal lobes are different for acute sufferers. Well, it would be if those upset experienced sweating and an increased heart rate. Effect is being labelled has the cause. This is a mistake!