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Synthetic Heart Repair Conduit

Treatment for heart disease is advancing at a rapid pace. Soon, a tiny piece of artery will be removed from a patient and a new heart conduit will be formed. This is for minor problems in the heart, less that 5mm wide.

Conduits are also being made from synthetic materials. Toleration of foreign substances is not a problems because it degrades quickly. They are used to go over the outside of a graft to stop bleeding. The synthetic conduits are made of a fine poly-(glycerol sebacate) net coated with polycaprolactone and the anticoagulant heparin. Mesh holes are too small for blood to pass through. Nothing of the implant remains after three months. A new structure of endogenous cells with M2 macrophages (which reduces inflammation) remains.

Though tests have only been done on rats, use in humans will probably be just as successful. Large grafts using the material will be done to see if this is feasible. This will be a welcome advance in medicine. A graft made of the body's own tissue will last much longer and patients will not need to be treated again for obstruction in the new graft.
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