Drinking alcohol is not an innocent pastime. We know it damages the liver. However, a link has been found between binge drinking and the onset of type 2 diabetes. How it does this is not fully understood.
Rats were put on a "diet" of 3 g/kg of alcohol for only three days. Even when the alcohol had completely left their systems insulin resistance was still occurring. The effect lasted 54 hours after ingestion of alcohol had ceased.
Impaired adipose tissue and hepatic functions were believed to be the cause. There was more hypothalamic inflammation affecting insulin signaling.
There is hope for a treatment. Inhibiting brain protein tyrosine phosphatase 1B (PTP1B) can block the detrimental action on insulin of binge drinking,